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MOT-C
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MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino-acid peptide naturally encoded in your mitochondrial DNA. It functions as a systemic hormone-like signal, optimizing cellular energy production and metabolic flexibility while mimicking the molecular adaptations of high-intensity exercise.
How It Works
MOTS-c targets skeletal muscle and other tissues to regulate how the body uses glucose and fat. It acts primarily by inhibiting the folate cycle, which causes AICAR to accumulate. This buildup activates AMPK (the body's master energy sensor), shifting your cells toward fat oxidation and boosting insulin sensitivity.
Key Benefits
Metabolic Health: Studied for its ability to improve insulin sensitivity, potentially protecting against diet-induced obesity and type 2 diabetes.
"Exercise Mimetic": Activates many of the same metabolic pathways as physical training, showing promise for improving physical capacity and endurance.
Longevity: Endogenous levels naturally decline with age. Research in mice suggests that supplementing MOTS-c can reverse age-dependent physical decline and support healthy aging.
Usage and Safety Considerations
Administration: Because it is quickly broken down by digestion, MOTS-c is administered via subcutaneous injection (typically 5–10 mg, several times per week).
Regulation & Sourcing: MOTS-c is not FDA-approved and remains classified as an experimental agent. The World Anti-Doping Agency (WADA) prohibits its use by athletes under Section 4.4 (Metabolic Modulators). Any use of this peptide should be under the strict supervision of a licensed physician who can acquire it through an authorized compounding pharmacy.